HGF/MET signaling can stimulate various downstream signaling pathways in tumor cells, such as PI3K/AKT, JAK/STAT, Ras/MAPK, SRC, and Wnt/β-catenin [82], and it can enhance tumor malignancy by inducing biological processes such as tumor proliferation, invasion, and metastasis [76]. Here, HGF is linked to neoplasm.