Although the expression of different inflammasome components including NLRP1, NLRP3, NLRC4, ASC, caspase-1, and the proinflammatory cytokines IL-1β and IL-18 increases in the initial hours and early days after ischemia in the brain of rodents [183,189], mitochondrial destabilization or dysfunctions are tightly associated with only NLRP3 inflammasome activation [61,190,191]. Here, NLRP3 is linked to ischemia.