HDAC4 and Miyoshi myopathy: Similarly, miR-29b mimics down-regulated proliferative and anti-apoptotic pathways in MM cells such as MCL-1, CDK6 and SP1 [145] in addition to other epigenetic regulators [146] including DNA methyltransferase three alpha/beta (DNMT3A/B) [147] and Histone Deacetylase 4 (HDAC4) [148].