ALK and anaplastic large cell lymphoma: We first confirmed endogenous miR-7-5p downregulation upon NPM-ALK inactivation, using pharmacological (crizotinib, Crizo) (Figure 1E) or molecular (siRNA targeting ALK, siALK) (Figure 1F) approaches, by performing miRNA RT-qPCR in two NPM-ALK-positive ALCL cell lines, Karpas-299 and SU-DHL-1 (Figure 1B,C).