Multiple studies have established a connection between Nrf2 and different liver diseases including alcoholic liver disease, metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic steatohepatitis (NASH), viral hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.