The acetylenic tricyclic bis(cyano enone), TBE-31, reversed insulin resistance and decreased liver steatosis, fibrosis, and oxidative stress in the livers of C57BL/6 mice; these effects were not observed in Nrf2-KO mice, demonstrating that they were Nrf2-dependent [40]. The gene discussed is NFE2L2; the disease is Hepatic steatosis.