Nrf2 activation ameliorates methionine- and choline-deficient (MCD) diet-induced hepatic steatosis, inhibiting Cluster of differentiation 36 (CD36), Fibroblast growth factor 21 (Fgf21), and PPARα expression in the liver of mice [45], whereas Nrf2 deletion increases PPARα expression [3,40,46]. This evidence concerns the gene NFE2L2 and fatty liver disease.