MDM2 and colorectal carcinoma: Accordingly, different types of really interesting new gene (RING) finger E3 ligases have been assigned to be critically involved in the development of CRC including RING finger proteins (RNFs), the murine double minute 2 (Mdm2) protein, the inhibitor of apoptotic proteins (IAPs), and the tripartite motifs (TRIMs) just to name a few of them [23].