TGFB1 and colorectal carcinoma: Although not particularly highlighted in CRC, many of the TRIMs previously described as modulators of other main oncogenic signaling pathways—including NF-κB, STAT3, Wnt/β-catenin, TGFβ, and PI3 kinase—may indirectly affect the outcome of apoptosis and consequently, the responses of colon carcinoma cells toward chemotherapeutic drugs (Figure 1).