By elucidating the underlying mechanisms in human CRC lines, Sun and colleagues demonstrated that overexpression of TRIM29 inhibits β-catenin phosphorylation at Ser33 /Thr41 by GSK3β which in turn leads to an increase in β-catenin level due to its impaired proteasomal degradation (Figure 2B) [71]. This evidence concerns the gene TRIM29 and colorectal carcinoma.