Although not particularly highlighted in CRC, many of the TRIMs previously described as modulators of other main oncogenic signaling pathways—including NF-κB, STAT3, Wnt/β-catenin, TGFβ, and PI3 kinase—may indirectly affect the outcome of apoptosis and consequently, the responses of colon carcinoma cells toward chemotherapeutic drugs (Figure 1). This evidence concerns the gene STAT3 and colorectal carcinoma.