Conversely, the increased migration and invasion of the normal colon epithelial cells upon overexpression of TRIM59 was prevented by a pharmacological inhibitor of PI3K (LY294002), thus supporting the functional impact of the PI3K/Akt pathway in the promotion of CRC cell migration and invasion and its regulation by TRIM59 (Figure 3B) [80]. This evidence concerns the gene TRIM59 and colorectal carcinoma.