While the majority of TRIM proteins have been assigned to act mainly as oncogenes due to the bad prognosis and outcome of patients with high tissue expression levels of the corresponding TRIM protein, only a few members including TRIM3 [33], TRIM8 [34], TRIM15 [35], TRIM45 [36], TRIM58 [37], and TRIM68 [38] can elicit tumor suppressive activities. The gene discussed is TRAT1; the disease is neoplasm.