TRIM14 promotes colorectal cancer cell migration and invasion, mainly through induction of sphingosine kinase 1 (SPHK1) which by increasing the synthesis of sphingosine 1-phosphate (S1P) promotes activation of STAT3 in CAC [134] as well as in sporadic CRC (Figure 4A) [55]. Here, SPHK1 is linked to colorectal cancer.