Alternatively, the low expression of the tumor-suppressive TRIM8, mainly observed in renal cell carcinoma but also in tissues from CRC patients (The Human protein Atlas, available from http://www.proteinatlas.org) and in the CRC cell line HCT116 [42], is inversely correlating with an overexpression of micro RNAs (miRs)-17-5p and miR-106-5p both of which are members of the miR-17-92 cluster. Here, TRIM8 is linked to colorectal carcinoma.