These findings fit to our previous studies which demonstrated that knockdown of TRIM25 via upregulation of the pro-apoptotic caspase-2 similarly sensitizes wild-type p53 (RKO) and p53 mutated (DLD-1) CRC cells to DNA-damage-induced apoptosis [64] thus inferring that some TRIMs exert anti-apoptotic programs which do not rely on the inhibition of p53. This evidence concerns the gene TP53 and colorectal carcinoma.