Studies examining the effect of these SNPs on gene function as well as associations between genotype/haplotype and immune cell subsets, serum cytokine levels, PDL-1 status, tumor mutational burden, and pathologic features (e.g., poor differentiation, tumor infiltrating lymphocytes, mucinous histology) may provide mechanistic explanations for the observed findings and better characterize the link between genotype and clinical outcomes. The gene discussed is CD274; the disease is neoplasm.