However, general information about the relevance of CX3CL1 and CX3CR1 in ALS is rather rare, except that disruption of MN-microglia communication as the result of CX3CR1 receptor deficiency in transgenic SOD1G93A mice accelerates disease progression and exacerbates neuronal death [21]. Here, CX3CR1 is linked to amyotrophic lateral sclerosis.