Typically, different cellular stimuli, including TNF, FAS ligand (also known as CD95L and APO-1L; Holler et al., 2000), TNF-related weak inducer of apoptosis (TWEAK; Wilson and Browning, 2002), TNF-related apoptosis-inducing ligand (TRAIL, also known as APO-2L), pathogen-associated molecular patterns, double-stranded RNA or DNA, interferons (IFNs), ATP depletion, ischemia‒reperfusion (I/R) injury, and some anti-cancer drugs (Huang et al., 2013), have been shown to induce necroptosis. Here, TNFSF12 is linked to cancer.