For example, circHIPK3 promoted proliferation of human tumor cells by binding with multiple miRNA, and a research team showed that circ-SHPRH, circ-FBXW7, and circ-PINT suppressed human glioblastoma growth through direct protein translation (Zheng et al. 2016, Yang et al. 2018, Zhang et al. 2018a). The gene discussed is SHPRH; the disease is neoplasm.