As proof of concept, we chose four H. arabidopsidis candidate genes as HIGS targets, for which we presumed that gene knockdown would affect pathogen infection, namely the housekeeping gene ACTIN A (HaACTRNAi), the CYSTEINE-RICH1 protein gene (HaCR1RNAi), an ALDOSE-1-EPIMERASE (HaA1ERNAi) gene, and the type-III RNA endonuclease gene DICER-LIKE1 (HaDCL1RNAi). The gene discussed is ARHGAP17; the disease is infection.