ADAMTS6 and malignant colon neoplasm: Subsequently, we conducted wound-healing assays to further examine cell migration in colon cancer cells and the results indicated that ADAMTS6 depletion significantly decreased NCI-H508 cell migration (P <0.01, Figure 5A,B), whilst ADAMTS6 overexpression fortified the migratory ability of Caco-2 cells (P <0.01, Figure 5C,D).