SHBG and type 2 diabetes mellitus: Given studies have identified associations between SHBG and risk of T2D independent of testosterone and a direct role of SHBG in mediating signalling on target cells, insufficient controls for SHBG may lead to residual pleiotropic effects (Lakshman et al., 2010; Rosner et al., 2010; Vikan et al., 2010).