ATXN3 and neurodegenerative disease: In fact, a Glc hypometabolism has also been reported for other polyglutamine diseases such as SCA2, SCA3, SCA6 [24], and Huntington’s disease [25] as well as for neurodegenerative diseases without trinucleotide repeats such as Alzheimer’s disease [26], amyotrophic lateral sclerosis [27], and Parkinson’s disease [28].