SHBG and obesity due to melanocortin 4 receptor deficiency: Particularly, the reduction of sex hormone-binding globulin (SHBG) serum levels, the increased androgen aromatization into estrogens, and the pro-inflammatory cytokine-dependent attenuation of luteinizing hormone (LH) pulses [2] represent some of the mechanisms explaining the occurrence of male hypogonadism in overweight and obesity [3].