A previous study [20] reported that FAT4 expression is remarkably decreased in gastric cancer tissues and is lower than that in non-cancerous adjacent tissues, which causes Yap nuclear translocation, noticeably, such a mechanism of FAT4 is correlated with poor prognosis, that is to say, tumor infiltration, lymph node metastasis and lower cumulative survival. The gene discussed is FAT4; the disease is neoplasm.