ENO2 and polycystic ovary syndrome: Although, treatment with NSE had no effect on the gene expression of Cyclin B., the Mapk mRNA expression in both control (1.85 ± 0.06 vs 0.96 ± 0.18, p = 0.025) and PCOS (1.2 ± 0.09 vs 0.47 ± 0.13, p = 0.0067) mice oocytes was significantly higher in 50 μg/ml NSE-treated oocytes than in the untreated (Figure 3).