Cox2 mRNA expression was significantly decreased in the 50 μg/ml NSE-treated oocytes as compared to the untreated in both control (0.82 ± 0.08 vs 1.33 ± 0.08, p = 0.047) and PCOS (1.09 ± 0.06 vs 1.63 ± 0.08, p = 0.035) groups. Here, ENO2 is linked to polycystic ovary syndrome.