Therefore, oral pyruvate as a novel strategy, other than current advances with sodium glucose linked transporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists [2], treated diabetic status and DN specifically by restoration of regular glucometabolic pathways with promoting glycolysis and glucose oxidative phosphorylation to drive the HG-induced Warburg effect backwards in kidneys of the experimental diabetic db/db mice. This evidence concerns the gene GCG and liver dysplastic nodule.