This result may be associated with the following reasons: the first one is that the IDH wild-type gliomas show larger intratumoral heterogeneity due to its increased cell proliferation and necrosis [7, 20], so the entire tumor ROI contained areas of necrosis and systs will lead to more higher ADC values, larger StDev, and inhomogenity. Here, IDH1 is linked to central nervous system cancer.