According to our results, CDH5, PECAM1, and VWF were DEGs we screened with the threshold of ∣log2FC | >2.0 and p < 0.05, and they were hub genes in the PPI network; their expression in normal lung and LUAD was verified in the Oncomine database, and their expressions were significantly related to the prognosis of lung cancer and LUAD patients; moreover, there is a tendency towards cooccurrence between CDH5, PECAM1, and VWF in LUAD. Here, VWF is linked to lung cancer.