AKT1 and hepatocellular carcinoma: It was reported that CD44 promoted HCC CSC stemness by regulating natural killer (NK) sensitivity or the tyrosine-protein kinase-Met-class I phosphoinositide 3-kinase-protein kinase B (c-Met-PI3K-AKT) signaling cascade, leading to poor prognoses of cancer and chemoresistance [28, 29].