The IL-33 gene, located on chromosome 9 (9p24.1), binds to ST2 and forms a trimer with IL-1R accessory protein (IL-1RAcP), which recruits downstream signaling molecules through the Toll/IL-1R (TIR) domains of ST2. The signaling pathways of nuclear factor kappaB (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinase (MAPK) are then activated, and the subsequent upregulation of the gene expression of proinflammatory cytokines leads to hepatic fibrosis [17–19]. The gene discussed is IL1R1; the disease is Hepatic fibrosis.