Additionally, reduced protein kinase C-mediated phosphorylation of the intermediate filaments vimentin and GFAP leads to an astrogliosis-like phenotype in hiPSC-derived NPC astrocytes, suggesting that gliosis is a primary effect of the cholesterol accumulation within glial cells and not a secondary mechanism mediated by the neuronal loss in NPC (Peter et al., 2017). Here, GFAP is linked to nasopharyngeal carcinoma.