RNASE1 and neoplasm: For instance, a protein-based delivery system named RNase A-NBC is responsive to ROS designed through a convenient chemical conjugation of 4-nitrophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzyl carbonate (NBC) with the lysine residues of RNase A. These RNase A-NBC NPs present with minor cytotoxicity against normal cells but selective inhibition cytotoxicity against tumor cells because of the high concentration of ROS in malignant cells compared with the healthy cells.