CDK6 and neoplasm: They are important in chronic lymphocytic leukemia by targeting Bcl-2 mRNA and decreasing of their expression results in the development of an autonomous lymphoproliferative disorder.15,16 Another tumor suppressor miRNA that has received substantial attention is miR-34 which is involved in tumor cell cycle by regulation of CDK4 and CDK6 expressions, and also metastasis proteins such as MET, Notch, MYC and AXL expression.17