For example, miRNA-21 is an oncomirRNA that can repress expression of tumor suppressor protein PDCD4 in colorectal cancer by recognizing and interacting with 3’UTR of messenger RNA.11 Another miRNA that becomes upregulated is miR 210 which modulates the expression of proteins involved with SHDH, a tumor suppressor that has a role in HIF1α expression and causes lung cancer cell survival.12 Binding of miR-10b in HOXD10 mRNA also initiates gene translation repression and leads to metastasis of breast and ovarian cancer.13,14. The gene discussed is HIF1A; the disease is ovarian cancer.