They are important in chronic lymphocytic leukemia by targeting Bcl-2 mRNA and decreasing of their expression results in the development of an autonomous lymphoproliferative disorder.15,16 Another tumor suppressor miRNA that has received substantial attention is miR-34 which is involved in tumor cell cycle by regulation of CDK4 and CDK6 expressions, and also metastasis proteins such as MET, Notch, MYC and AXL expression.17 This evidence concerns the gene CDK4 and neoplasm.