GAS6 and neoplasm: Necrotic cells can release pro-inflammatory factors, such as IL-1α into tumor microenvironment.5 TAMs promote the survival of inflammatory breast cancer IBC by expression of gene encoding the AXL/GAS6 (growth arrest- specific protein 6) signaling.43 Versican, an extracellular proteoglycan, which activate macrophages via TLR2 and TLR6 in lung cancer.