Recent study identify that TLR ligands promote repolarization of macrophage in mouse models.96 Additionally, combination of TAM repolarization with checkpoint inhibitors (PD1 or CTLA4 antagonists), stimulating antibodies (CD40 or GITR agonists) and radiotherapy displayed a remarkable strategies for cancer treatment.97 Vessel normalization susceptible tumor cells to chemotherapy agents. The gene discussed is CD40; the disease is neoplasm.