Depletion of macrophages by liposomal clodronate before IR and the inhibition of CSF1 receptor with PLX3397 can promote the anti-tumor effect of RT.94 Crittenden and his colleagues reported that high doses of irradiation produce M2 phenotype through p50–p50 NFκB homodimer activation and IL-10 production. This evidence concerns the gene CD40 and neoplasm.