CASP8 and neoplasm: This function mediated by activation of caspase-8, which plays pivotal role in the extrinsic apoptotic signaling pathway via Fas and TNF-related apoptosis inducing ligand receptors.78 Liposome-encapsulated bisphosphonate clodronate can be phagocytized by macrophages leads to macrophages deletion and inhibit tumor progression.