TNFRSF18 and melanoma: PPAR-γ express in adipose tissue, colon and macrophages and regulate fatty acid storage and glucose metabolism.35 TLR4 agonist like heat-treated Mycobacterium indicus pranii (Mw) in combination with DTA-1(an agonistic antibody for glucocorticoid-induced TNFR-related protein (GITR)) induce the repolarization of TAMs into M1-like macrophages by a significant increase in IL-12, iNOS and HLA-DR in a mouse model of advanced stage melanoma.36