Recent study identify that TLR ligands promote repolarization of macrophage in mouse models.96 Additionally, combination of TAM repolarization with checkpoint inhibitors (PD1 or CTLA4 antagonists), stimulating antibodies (CD40 or GITR agonists) and radiotherapy displayed a remarkable strategies for cancer treatment.97 Vessel normalization susceptible tumor cells to chemotherapy agents. This evidence concerns the gene CTLA4 and neoplasm.