It was reported that C57BL6 mice with macrophages expressing or missing LDLR have enhanced level of macrophage LDLR on lipid buildup in the artery wall and atherosclerotic lesion progress.74 Significant more small lesions have been observed in animals receiving LDLR bone marrow in comparison with those receiving normal bone marrow; hence, it could be said that the number of foam cell formation inside the artery wall is affected by macrophage LDLR, leading to atherosclerosis development ultimately. The gene discussed is LDLR; the disease is atherosclerosis.