CDH1 and Familial gastric cancer: When exon 3 in both the patients was analyzed, the same deletion was found on chromosome 16q22.1, thus establishing a germline mutation between the two patients [27]. A study was conducted among 38 families to establish the germline CDH1 mutation link in cases with diffuse gastric cancer where four families from Newfoundland in the study were found to have a common haplotype mutation which causes both DGC and ILBC and two families among the four had later on developed lobular breast cancer.