CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome: With the current study showing a strong association between CDH1 and HDGC with 88% of DGC patients positive for CDH1 mutations and almost all of them with positive signet ring cell changes on microscopy on screening, awareness for an early preventive or curative approach is needed. The treatment modalities currently recommended by IGCLC are for a prophylactic total gastrectomy in the carriers.