CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome: The rising trend of increased HDGC cases can also be proven from the fact that countries like Japan, China, Korea and other south east Asian countries, where gastric cancer is most commonly attributed to the Helicobacter pylori infection or a high-spice diet, are seeing an increase in number of HDGC predominantly due to CDH1 mutations.