The relation of E-cadherin mutations with invasive lobular breast carcinoma and gastric carcinoma was well established by various studies with loss of expression of E-cadherins on the apical luminal epithelial cells of the breast results in ILBC and their missense or in-frame deletions in development of HDGC proved their role in tumorigenesis and metastasis [17]. These mutations resulted in the intracellular activation of the above signaling pathways in the cells which led to tumor growth and invasion. This evidence concerns the gene CDH1 and Familial gastric cancer.