The role of E-cadherin is the calcium dependent cell-cell interaction and thus maintaining tissue architecture but in malignancies, this interaction breaks and cell-cell homeostasis is imbalanced, so in simple terms, cancers are uncontrolled proliferation of tissue cells and one of the transmembrane glycoprotein, E-cadherin, is responsible to prevent that uncontrolled proliferation [14]. Here, CDH1 is linked to cancer.