CDH1 and neoplasm: The relation of E-cadherin mutations with invasive lobular breast carcinoma and gastric carcinoma was well established by various studies with loss of expression of E-cadherins on the apical luminal epithelial cells of the breast results in ILBC and their missense or in-frame deletions in development of HDGC proved their role in tumorigenesis and metastasis [17]. These mutations resulted in the intracellular activation of the above signaling pathways in the cells which led to tumor growth and invasion.