CDH1 and Familial gastric cancer: In a study conducted among 183 patients who met the IGCLC clinical criteria for HDGC, almost 20% of the cases showed a definite CDH1 mutations and the lifetime risk of developing HDGC was found to be between 60-80% in males and almost 60% in females and the lifetime risk of developing ILBC was found to be more than 42% with the same CDH1 mutations [10].