Depicted in Table 4 are the genes which were found to be associated with no pathological E-cadherin variant with most of these being DNA repair genes where a single protein was affected resulting in a germline mutation and the gene which was best recognized to play a significant role in development of HDGC in non-CDH1 mutational carriers was found to be PALB2 [50]. The age of diagnosis for these tumors with the said gene mutations ranged from 22-83 years with 27% of the families studied were found to have non-CDH1 gene mutations and were diagnosed with HDGC [50]. This evidence concerns the gene CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome.