CDH1 and Familial gastric cancer: A study by Keller et al. in 1999 was one of the first studies to establish a link between breast carcinoma, diffuse gastric carcinoma and CDH1 germline mutation where a basepair (bp) deletion on exon 3 was detected in a patient suspected with diffuse gastric carcinoma - with patient having a strong young age family history of DGC and the mother of the patient was diagnosed with both diffuse gastric cancer and lobular breast cancer [27].