Williams et al. observed that both AST and ALT levels rose with the progression of liver damage, specifically in patients with chronic hepatitis, and a ratio of AAR >1.0 would typically suggest cirrhosis with 100% specificity and a PPV in distinguishing cirrhotic from non-cirrhotic patients, with a 53% sensitivity and 81% NPV [17-18]. The gene discussed is GPT; the disease is Cirrhosis.