1. Non-survivors COVID-19 patients had a higher level of D-dimers, prothrombin time and fibrin degradation products (FDPs) as compared to the survivors. 2. Higher levels of D-dimers were associated with an increased mortality in patients with COVID-19, p<0.001. 3. Non survivors COVID-19 patients had higher level of D-dimers [5·2μg/mL(1·5–21·1)] as compared to survivors [0·6μg/mL (0·3–1·0)], (p<0.0001). Here, F2 is linked to COVID-19.