Accordingly, we have investigated the microenvironment-mediated disruption of lymphopoiesis in pro-inflammatory ALL BM (Balandrán et al. 2017;) and identified by computational modelling CXCR7 as an emergent CXCL12 chemokine receptor playing a potential role in the intercellular communication between hematopoietic precursors and mesenchymal stromal cells (MSC) when intermittent or continuous TLR agonist signals are present (Enciso et al., 2016; Tarnowski et al., 2010). This evidence concerns the gene ACKR3 and acute lymphoblastic leukemia.