CXCR4 and neoplasm: In a previous work, we reported the NFkB-induced expression of CXCR7 concomitant to the perturbation of the CXCR4/CXCL12 and VCAM-1/VLA-4 integrin axes (Enciso et al., 2016), consistent with experimental evidence of its involvement in immune cell recruitment and tumor metastasis (Alampour-Rajabi et al., 2015; Tarnowski et al., 2010; Torossian et al., 2014; Chang et al., 2018).