ACKR3 and Bone marrow hypocellularity: This emphasize the substantial need of promoting feedback loops between experimental and computational research to investigate the potential participation of CXCR7 in migration/homing of early precursors to unique activating microenvironments in lymphoid-related pathologies where inflammation functions as a cooperative element, such as acute leukemia, bone marrow failure, acute and chronic viral infections, sepsis, metabolic and autoimmune diseases, among others.