Although CXCL12/CXCR4 axis has been considered the most important player in chemotaxis, support and retention of hematopoietic cells into their BM niches (Sugiyama et al., 2006), MSC isolated from patients suffering hematological diseases have shown dysregulation of CXCL12 and stem cell factor (SCF) concomitant to a pro-inflammatory microenvironment (Colmone et al., 2008; Balandrán et al., 2017; Vilchis-Ordoñez et al., 2015). The gene discussed is KITLG; the disease is hematologic disorder.