As mentioned, CXCR7 has been extensively documented in the pathobiology of an increasing number of systemic diseases, including inflammation (rheumatoid arthritis, obesity), cancer (prostate, colon, bladder, ovarian, cervical, uterine, kidney, liver, stomach, lung, breast and hepatocelular), neurological conditions, infectious and other complex diseases, like autism and atherogenesis (reviewed in Lounsbury, 2020). This evidence concerns the gene ACKR3 and obesity due to melanocortin 4 receptor deficiency.