ADAM8 and pancreatic adenocarcinoma: Among these DEGs, significantly higher expression of ADAM8/9/10/12/15/19/28/TS2/TS12 were identified with log2FC from 2.194–3.53 (all P < 0.001) (Table 1), which implied that all these ADAMs were over-expressed in PAAD (Fig. 1).