Specifically, five m6A writers (METTL14, METTL16, KIAA1429, RBM15 and ZC3H13) were upregulated in PAAD, and seven m6A readers (YTHDF1, YTHDF2, YTHDF3, IGF2BP2, IGF2BP3, HNRNPA2B1 and HNRNPC) were highly expressed in PAAD. The gene discussed is YTHDF3; the disease is pancreatic adenocarcinoma.