PROS1 and Sepsis: Venous insufficiency with cutaneous infarction and disseminated intravascular coagulation can appear in the context of severe sepsis; however, it can also be due to a congenital deficit of protein C or protein S. Classically, it has been related to the most serious forms of meningococcal sepsis, but it can also be present in sepsis due to Haemophilus, Streptococcus, Staphylococcus, or less frequent germs such as Rickettsia, especially in anaesthetic patients [42–44].