NRXN1 and neoplasm: Although the results of cell growth inhibition and the apoptosis assay in the present study imply the internalization of the anti-NRXN1 antibody with the secondary ADC because of the significant anti-tumor effects that were observed, the internalization, efficiency of the internalization, and intracellular trafficking of NRXN1-mediated ADCs should be addressed in future research using optimized monoclonal antibodies directly conjugated to payloads.