EDNRA and hypertensive disorder: A recent study showed that SalA is a safe endothelin-1 type A receptor (ETAR) antagonist (IC50 = 5.7 μmol/L) in HEK293 cells overexpressing ETAR [59], suggesting that SalA may be effective in treating hypertension because endothelin-1 is a potent vasoconstrictor.