NLRP3 and infection: Moreover, Cohen et al. confirmed that Vibrio proteolyticus (VPRH), a Gram-negative bacterium from the gut of a wood borer, induces pyroptosis by activating the NLRP3 inflammasome and caspase-1, thereby resulting in IL-1β secretion, suggesting that the NLRP3 inflammasome pyroptotic pathway can benefit the host during infection [55].