The SCA individuals who carried the minor allele (T) of the TGFBR3 rs7526590 polymorphism also presented increased RDW and higher indirect markers of intravascular hemolysis, such as AST, IB, and LDH, as well as decreased ferritin levels, which is suggestive of an association with hemolysis. Here, TGFBR3 is linked to hemolysis.