At present, we also determined the influence of trilobatin on insulin resistance in ob/ob mice, the results demonstrated that treatment with 10 mg/kg trilobatin (intragastric, i.g.)for 4 weeks noticeably decreased fasting blood glucose (Fig. 7a) and insulin in serum (Fig. 7b), which was confirmed by the homeostasis model assessment of insulin resistance (HOMA-IR), a simple and efficient tool to evaluate the syndrome of insulin resistance (Fig. 7c). This evidence concerns the gene INS and Insulin resistance.