However, we did not observe a significant upregulation of PVRL2 (Figure 3(b)), CSF1R (Figure 3(c)), TGFBR1 (Figure 3(d)), VTCN1 (Figure 3(e)), LGALS9 (Figure 3(f)), IL10RB (Figure 3(g)), KDR (Figure 3(h)), and IDO1 (Figure 3(i)) in advanced grades of PC samples. The gene discussed is IDO1; the disease is pachyonychia congenita.