In the present study, L-GSPE and H-GSPE treatment significantly reduced blood glucose, kidney weight, HOMA-IR, renal index, increased insulin, and body weight of the rats, though the L-GSPE group was slightly worse than the H-GSPE group in reducing HOMA-IR and renal index, but the overall data still indicate that L-GSPE and H-GSPE groups both of them have a significant protective effect against diabetes. The gene discussed is INS; the disease is diabetes mellitus.