PAK4 and cancer: Kaempferol has shown a good affinity for PAK4 in molecular docking and is considered to be a potential inhibitor in triple-negative breast cancer [34], and kaempferol can prevent G2/M phase of the cell cycle by downregulating CDK1 in human breast cancer MDA-MB-453 cells [35], and blocking RhoA and Rac1 signaling pathways to inhibit breast cancer cell migration and invasion [36] is a powerful antioxidant inducer and can inhibit oncogene transformation and induce cancer cell apoptosis and DNA damage.