Increased HPG axis stimulation may be associated with reproductive function restoration for PCOS women, while overstimulation of this pathway axis produces downregulation of reproductive hormone secretion, and KISS-1 is found to have a role in treating prostate and breast malignancies, as well as benign hormone-dependent disorders as benign prostate hyperplasia and endometriosis, through its act as a suppresser in the metastatic cascade [22]. This evidence concerns the gene KISS1 and endometriosis.