Transplantation of BMSCs was capable of improving cognitive impairment via upregulating the hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion (via upregulating hippocampal GABA, GAD67, and GABABR1 expression in a rat model of chronic cerebral hypoperfusion) [35, 71]. Here, GABBR1 is linked to Cognitive impairment.