MKI67 and esophageal squamous cell carcinoma: MKI67, also known as Ki-67, acts as a biological surfactant to disperse mitotic chromosomes (Cuylen et al., 2016), which has been demonstrated in various carcinomas, including gastric, esophageal, colonic, rectal, and esophageal squamous cell carcinoma (Volkweis et al., 2012).