ZBTB16 and Insulin resistance: We showed earlier that SHR-Lx congenic strain carrying the same 2 kb-deletion in an intron of Zbtb16 as the SHR-Zbtb16 strain displays higher sensitivity to dexamethasone-induced insulin resistance of the skeletal muscle when compared to SHR controls (Seda et al., 2005) and this effect was persistent in SHR-Zbtb16 itself (Krupkova et al., 2018).