Although this observation did not translate to change of global glucose tolerance in the programmed rat offspring, subtler change in insulin resistance of peripheral tissues cannot be excluded, as suggested by the 3-fold (2-fold in SHR-Zbtb16) reduction of Glut4 expression in white adipose tissue of SHR male offspring and, in a network perspective, the glucose metabolism disorder activated node. This evidence concerns the gene INS and glucose metabolism disease.