The assay revealed that the half-life of PEDF gene transcripts was shortened in SU-DHL4 and HBL1 cells with silenced expression of METTL3 (Figure 3J), suggesting that decreased expression of PEDF in the DLBCL cells with METTL3 silencing can be at least partially attributed to reduced mRNA stability of PEDF linked to altered m6A methylation level. The gene discussed is LINC00458; the disease is diffuse large B-cell lymphoma.