Of all different post-translational modifications that tau can undergo, the phosphorylation is of particular interest because of its involvement in a group of neurodegenerative disorders known as tauopathies (Goedert and Spillantini, 2011; Arendt et al., 2016), including Alzheimer’s disease (AD). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.