Extracellular vesicles containing phospho-tau were found in the brains of transgenic mice (Baker et al., 2016; Polanco et al., 2016) and in peripheral fluids such as blood or CSF of AD patients (Saman et al., 2012; Fiandaca et al., 2015; Winston et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.