MAPT and Alzheimer disease: Indeed, several studies have shown that the interaction between Aβ and tau can exaggerate AD pathology (Ribé et al., 2005; Bennett et al., 2017; He et al., 2018; Vergara et al., 2019) and that amyloid deposition, preceding the NFT formation, can actively influence tau spreading to neocortical regions (Braak and Braak, 1997; Hardy and Selkoe, 2002; Jacobs et al., 2018; Vogel et al., 2020).