PSEN1 and Alzheimer disease: Adult 3xTg-AD mice (humanized mice that express human MAPT, APP, and PSEN-1 transgenes and manifest AD-like pathologies) given two-bottle home-cage alcohol/saccharin (25% w/v + saccharin 0.1%, w/v) for four months showed impaired spatial memory, exacerbated conditioned fear, and diminished sensory gating in a chronic non-dependent drinking model.