IFNG and viral infectious disease: Transcriptomic and genomic studies have implicated alterations in key cytokines with SCZ, including increases in interferon regulatory factor 3 (IRF3) (Li et al., 2015), which is a major transcription factor in viral infection, and interferon gamma (IFN-γ), an important regulator of viral propagation (Paul-Samojedny et al., 2011).