Conversely, multiple studies have a found a decreased expression of CDH5 in the PFC of SCZ individuals, while genetic knockdown of CDH5 in mouse PFC led to BBB disruption and changes in behavior including deficits in learning, memory, sensorimotor gating, and anxiety-like behavior (Nishiura et al., 2017; Greene et al., 2018). This evidence concerns the gene CDH5 and Anxiety.