On the other hand, a local intravascular traumatic injury causing from ECs to SET/EVT damage (e.g., DVT), which results in additional local expression of TF, activates the TF/FVIIa complex-initiated fibrinogenetic path (i.e., TF path) as well as microthrombotic path (i.e., ULVWF path) at the local injury site. The gene discussed is TF; the disease is deep vein thrombosis.