Additionally, unlike false DIC, “true DIC” (e.g., APL) shows the feature of consumption coagulopathy, which includes decreased fibrinogen level, and decreased FVIII and FV activity because fibrinogen is consumed, and FVIIIa and FVa become inactivated after modulation via activated TF-induced fibrinogenetic path. This evidence concerns the gene TF and acute promyelocytic leukemia.