Whenever abnormal coagulation profile is encountered in a critically ill patient, the differential diagnosis should include 1) acute “DIC”, 2) EA-VMTD with hepatic coagulopathy, and 3) primary fibrinolysis because they often present with thrombocytopenia, hyperfibrinogenemia or hypofibrinogenemia, prolonged prothrombin time and activated thromboplastin time, and elevated D-dimer. Here, F2 is linked to Thrombocytopenia.