The first (ECs damage) activates ULVWF path to produce microthrombi; the second (ECs and SET damage) activates both ULVWF and sTF paths to produce macrothrombus within the intravascular space; the third (ECs and SET/EVT damage) activates both ULVWF path and TF (sTF/eTF) path to produce combined macrothrombus without or with hemorrhage/hematoma penetrating beyond the vessel wall and into EVT; and the fourth (EVT damage alone) activates only TF path due to major internal EVT injury and produces tissue hemorrhage/hematoma made of some fibrin clots and blood cells. This evidence concerns the gene TF and hemorrhage.