Additionally, unlike false DIC, “true DIC” (e.g., APL) shows the feature of consumption coagulopathy, which includes decreased fibrinogen level, and decreased FVIII and FV activity because fibrinogen is consumed, and FVIIIa and FVa become inactivated after modulation via activated TF-induced fibrinogenetic path. The gene discussed is F8; the disease is acute promyelocytic leukemia.