Limited damage to ECs causes microthrombogenesis to generate microthrombi (e.g., “DIC”; transient ischemic attack [TIA]), limited activation of TF path causes fibrinogenesis to form fibrin clots (e.g., APL with consumption coagulopathy; tissue hematoma [e.g., subdural hematoma]), and combined damage to ECs and SET/EVT causes macrothrombogenesis to form macrothombus (e.g., DVT; acute ischemic stroke) [60]. The gene discussed is TF; the disease is blood coagulation disease.